bind

Normally, alpha-synuclein's natural or "native state" is like a flexible strand, but when active it shapes itself into a helix, which is critical for its function in binding and transporting parcels of dopamine.

And he set out plans he said would ensure "sustained negative net migration" by setting a binding annual cap on immigration.

But finding yourself in a bind necessitates clever solutions, and Park’s already dark comedy turns jet-black as the director reveals that stress can beget new talents.

“That decision is binding, and it does require a substantial degree of deference on the factual issues,” Somin said.

The consultation also draws on other jurisdictions, including the Scottish system where there is more upfront information and earlier binding contracts.