most significant
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Perhaps the most significant implication of the research concerns a longstanding question in psychedelic medicine: Are hallucinations and altered states of consciousness necessary for the brain changes that might contribute to therapeutic benefits?
From Science Daily ● Nov. 7, 2026
The most significant game of Angelina Anderson’s season was also her worst.
From Los Angeles Times ● Nov. 6, 2026
And Lagarde’s departure will kick off one of the most significant leadership shake-ups in the central bank’s history, with jockeying to succeed her beginning in earnest on Thursday.
From The Wall Street Journal ● Oct. 29, 2026
One of the most significant risks to that ability is Anthropic's access to the infrastructure, including computer chips and data centres, it needs to build, train and operate the models that underpin its technology.
From BBC ● Oct. 26, 2026
Three days prior to the most significant date of his life, Glenn went through a final simulation, carrying out a full checkout of his flight plan.
From "Hidden Figures" by Margot Lee Shetterly
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