take it out of

exhaust

bankrupt burn out conk out debilitate do in drain draw enervate enfeeble fag fatigue frazzle impoverish overdo overexert overextend overfatigue overtire overwork peter out poop poop out prostrate run ragged sap suck dry tucker use up weaken wear down wear out weary

annoy bore depress dishearten exasperate exhaust fade irk tire

burden cloy debilitate disgust distress drain droop drowse enervate enfeeble fag fail fatigue flag glut harass jade nauseate oppress overwork pain plague sap sicken sink strain tax vex weaken weigh

cause ennui fall off grow tired have had enough leave one cold lose interest make discontented tire out try the patience of tucker out wear down wear out

comfort encourage excite invigorate make happy please refresh soothe

aid assist calm cure energize help increase mend rise strengthen

activate enliven