dermis

"The collagen will just sit on the outer layer of your skin, it won't reach the dermis - which is the middle layer."

In argyria, silver ions circulate through the bloodstream and become embedded in the dermis, a layer beneath the surface where the body cannot easily clear them.

Split-thickness grafts that contain mostly epidermis with only some of dermis can be used to cover larger areas, but they do not include features like hair and sweat glands, and are more prone to shrinkage and scarring.

They achieved both the hypodermis and dermis layers, with the epidermis forming within two weeks by itself.

As the skin undergoes photoaging, type I collagen bundles, which are found in the dermis beneath the top layer of the skin and provide strength and support to skin, become fragmented.