misfortune/mishap

accident adversity affliction annoyance anxiety bad break bad news blow burden calamity casuality cataclysm catastrophe contretemps cross crunch debacle disadvantage disappointment discomfort dole failure hard luck hardship harm inconvenience infelicity loss misadventure mischance misery nuisance reverse rotten luck setback stroke of bad luck tough luck tragedy trial tribulation trouble unpleasantness visitation worry

advantage benefit blessing fortune good luck