estranged

In one case, the mother has just one child, a daughter from whom she has become estranged.

Then there are the adult children estranged from their parents, who one day will be elderly and require care.

A recent New York Times article profiled parents estranged from their adult children.

As a soldier returning from Iraq, I felt both welcomed by and estranged from my tribe.

Earl tasks Phil with finding his estranged son, a pickup artist named Frank Mackey (Tom Cruise).

The memory of his father rose in his mind: he, too, estranged and defied; despair sharpened into wrath.

Then Bob had somehow kept his wife's love, and he, with senseless obstinacy, had estranged Helen.

You knew that I was estranged from my husband, and you knew what that so often means.

He was drawn into a series of deplorable controversies, which estranged him from many; but of his real friends he lost not one.

A short time ago they had been all in all to each other; and now so completely estranged as they were!