Definitions

systemic

[si-stem-ik] / sɪˈstɛm ɪk /

ADJECTIVE

affecting the entire system

Synonyms

STRONGEST

fundamental integral intrinsic

STRONG

essential innate

WEAK

congenital elemental ingrained inherent inseparable requisite

Antonyms

STRONGEST

extrinsic secondary

STRONG

supplemental unnecessary

WEAK

piecemeal

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"Seeing both central nervous system changes in brain scans and systemic changes in blood chemistry underscores that these mind-body practices are acting on a whole-body scale."

From Science Daily • Apr. 7, 2026

"We need to recognise this for what it is. A systemic issue. A growing issue. And one that demands a co-ordinated response across government, policing and industry," he added.

From BBC • Apr. 3, 2026

Sister Amy Duggar King said she wasn’t surprised by the allegations and arrest, telling People in an interview published Wednesday that there was a “deeper systemic issue” at play.

From Los Angeles Times • Apr. 1, 2026

Private credit is not a systemic crisis — but it does warrant careful evaluation and selectivity.

From MarketWatch • Mar. 30, 2026

The world of systemic insecticides is a weird world, surpassing the imaginings of the brothers Grimm — perhaps most closely akin to the cartoon world of Charles Addams.

From "Silent Spring" by Rachel Carson