irreconcilable difference

For here, in fact, we come to the irreconcilable difference.

The provincials were long separated from their Arian masters by the irreconcilable difference of religion.

Here, indeed, is the irreconcilable difference between two schools of mythological interpretation.

Like drift on a freshet, elements of irreconcilable difference were dashing pell-mell toward catastrophe.

I could well understand how there might be an irreconcilable difference between them.