bottom up

Built through a bottom-up molecular engineering strategy, they combine tightly controlled size with a defined number of surface ligands to create a multivalent platform with highly specific interactions at cellular receptors.

On the other hand, people who are a little bit below that level, they might feel a bit squished between bottom-up and top-down pressure.

The benefit to clients is marrying our top-down macroeconomic view with the bottom-up credit selection.

While news organizations are in many ways top-down institutions—newsroom editors exercise an autocracy quite rare in other fields—in reality they are bottom-up, their product shaped by those who wield the digital pens.

The US military "excels" because there is a "bottom-up" culture where units on the ground can make decisions as the situation evolves and alter their fighting strategies, Dr Raska notes.