malignancy

OPA1 is overexpressed in several cancer types and is linked with poor outcomes and therapy resistance in breast cancer, lung cancer and other malignancies.

By showing how interactions between immune and stromal cells drive these changes, the study offers a model for exploring inflammatory remodeling in other myeloid malignancies and advanced leukemia.

Not because cancer had been ruled out — it’s possible that the tests might have missed a subtle malignancy, still brewing.

"This is a very important finding because it provides insights into how blood cells develop, and can help to establish how alterations in Nup358 contribute to blood malignancies."

Ion channels are gateways within cells that tightly control the inward and outward flow of essential ions, such as potassium and calcium, and are thought to be critically linked to cancer malignancy and progression.