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MTB





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They live in the lung's alveoli, the tiny air sacs where oxygen passes into the bloodstream -- but, as Rothchild has shown in a previous paper, AMs don't mount a robust immune response when they're initially infected by Mtb.

From Science Daily

"Mtb takes advantage of the immune response," says Rothchild, "and when they infect an AM, they can replicate inside of it for a week or longer. They effectively turn the AM into a Trojan Horse in which the bacteria can hide from the body's defenses."

From Science Daily

"What if the AMs responded more effectively to Mtb? How could we change the body's innate immune response? Studies over the last 10 years or so have demonstrated that the innate immune system is capable of undergoing long-term changes, but we are only beginning to understand the underlying mechanisms behind them."

From Science Daily

In the second model, the researchers induced a contained Mtb infection, which they previously showed protects against subsequent infections in a form of concomitant immunity.

From Science Daily

Weeks after exposure, the researchers challenged the mice with aerosolized Mtb and infected macrophages were taken from each mouse model for RNA sequencing.

From Science Daily