debilitating

Sian Jones, 72, has suffered from recurrent "debilitating" urinary tract infections for more than 50 years, and has lost two premature babies as a result.

Prior to her diagnosis, Ms Boocock - who also has endometriosis - had lived with debilitating symptoms that left her regularly needing to use a walking stick.

While schools were beginning to return to normal, Avalyn was struggling with a deep and debilitating fatigue, and eventually left school for home education.

It was reported that she suffered from a debilitating infection known as the Epstein Barr virus, and from the chronic fatigue syndrome, ME.

And he accomplished his most significant work without the use of his hands or legs, which became effectively paralyzed after he contracted a rare and debilitating autoimmune condition called Guillain-Barré syndrome in 2003.