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Definitions

de novo

[dee noh-voh, dey, dih, de noh-woh] / di ˈnoʊ voʊ, deɪ, dɪ, dɛ ˈnoʊ woʊ /
ADJECTIVE
afresh
Synonyms
STRONGEST
anew once more
WEAK
again lately newly of late once again over over again recently
ADVERB
anew
Synonyms
STRONGEST
afresh once again once more recently
WEAK
another time come again from scratch from the beginning in a different way in a new way lately new newly one more time over over again

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

AI for the quantitative world is something else entirely, focusing on creating novel medical treatments, de novo material science, and advanced risk management and portfolio construction.

From The Wall Street Journal • Feb. 16, 2026

World Liberty Trust filed its de novo application Wednesday with the U.S.

From The Wall Street Journal • Jan. 7, 2026

"These de novo or reference-guided assemblers are pretty well-established tools that entail a whole operational pipeline with repeat detection or structural variants' identification being just some of their functionalities," Segarra said.

From Science Daily • May 7, 2024

“Currently … it goes through a de novo review before an administrative law judge, which means a new body of records is created,” she explains.

From Science Magazine • Nov. 28, 2023

The mitochondria do not arise de novo in cells; they are always there, replicating on their own, independently of the replication of the cell.

From "The Lives of a Cell" by Lewis Thomas