Ah, they are of their insignificance so loftily unconscious.
She took her insignificance, the absence of any soft emotion, quite calmly.
His first impression of his tutor was one of insignificance.
Meditate upon it, and on the insignificance and evanescence of human life.
Thus the great adventure of Redon dwindled to insignificance.
All else has faded into insignificance ...